Article

α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation

2025-01-13

Abstract excerpt

<h4>SUMMARY</h4> α-Synuclein aggregation is a hallmark of Parkinson’s disease and related synucleinopathies. Extracellular α-synuclein fibrils enter naïve cells via endocytosis, followed by transit into the cytoplasm to seed endogenous α-synuclein aggregation. Intracellular aggregates sequester numerous proteins, including subunits of the ESCRT-III system for endolysosome membrane repair, but the toxic effects of...

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Literature Corpus work: c2d1a14a-7bb0-51a6-bc5c-88f10b4842cb
DOI: 10.1101/2025.01.13.632710

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