Article

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

2023-06-17

Abstract excerpt

Aggregation of the protein tau is a hallmark of Alzheimer’s disease and other tauopathies. Specific neuronal subtypes are selectively vulnerable to tau aggregation, but the underlying mechanisms are unknown. To systematically uncover the cellular factors controlling the accumulation of tau aggregates in human neurons, we conducted a genome-wide CRISPRi-based modifier screen in iPSC-derived neurons. The screen unco...

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Literature Corpus work: 2edbc736-ed4c-552f-a441-cde3046846d4
DOI: 10.1101/2023.06.16.545386

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