Article

Alzheimer’s Disease risk modifier genes do not impact tau aggregate uptake, seeding or maintenance in cell models

2019-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) afflicts millions of people worldwide, and is caused by accumulated amyloid beta and tau pathology. Progression of tau pathology in AD may utilize prion mechanisms of propagation in which pathological tau aggregates released from one cell are taken up by neighboring or connected cells and act as templates for their own replication, a process termed “seeding.” In cultured...

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Literature Corpus work: 14139185-a1a4-5cc9-a367-686390cfed6e
DOI: 10.1101/809137

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