Article

A novel inducible mtDNA mutator mouse model to study mitochondrial dysfunction with temporal and spatial control

2025-04-21

Abstract excerpt

Mitochondrial dysfunction is a hallmark of aging and numerous age-related diseases. A wealth of studies supports the accumulation of mitochondrial DNA (mtDNA) mutations as a contributing factor to mitochondrial dysfunction in aging and disease. One of the best models to study the relationship between mtDNA mutations and mitochondrial dysfunction is the mtDNA mutator mouse, which expresses a proofreading-deficient...

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Literature Corpus work: 7cf40547-5550-59c1-9c37-a0d3ab4dfaa9
DOI: 10.1101/2025.04.17.649454

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