Article
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice.
PloS one - 7 Jul 2010
Hiona Asimina, Sanz Alberto, Kujoth Gregory C, Pamplona Reinald, Seo Arnold Y, Hofer Tim, Someya Shinichi, Miyakawa Takuya, Nakayama Chie, Samhan-Arias Alejandro K, Servais Stephane, Barger Jamie L, Portero-Otín Manuel, Tanokura Masaru, Prolla Tomas A, Leeuwenburgh Christiaan
Abstract excerpt
BACKGROUND: Aging results in a progressive loss of skeletal muscle, a condition known as sarcopenia. Mitochondrial DNA (mtDNA) mutations accumulate with aging in skeletal muscle and correlate with muscle loss, although no causal relationship has been established. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the relationship between mtDNA mutations and sarcopenia at the gene expression and biochemical levels...
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