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The mtDNA mutation spectrum in the PolG mutator mouse reveals germline and somatic selection.

BMC genomic data - 26 Nov 2021

Maclaine Kendra D, Stebbings Kevin A, Llano Daniel A, Havird Justin C

Abstract excerpt

BACKGROUND: Mitochondrial DNA (mtDNA) codes for products necessary for electron transport and mitochondrial gene translation. mtDNA mutations can lead to human disease and influence organismal fitness. The PolG mutator mouse lacks mtDNA proofreading function and rapidly accumulates mtDNA mutations, making it a model for examining the causes and consequences of mitochondrial mutations. Premature aging in PolG mice...

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Aging, Premature
DNA, Mitochondrial
DNA Mutational Analysis
DNA Polymerase gamma
Germ Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reactive Oxygen Species

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PMID: 34823474
DOI: 10.1186/s12863-021-01005-x
PMCID: PMC8620558

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