Article
Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse.
Human molecular genetics - 15 May 2012
Dillon Lloye M, Williams Siôn L, Hida Aline, Peacock Jacqueline D, Prolla Tomas A, Lincoln Joy, Moraes Carlos T
Abstract excerpt
Aging is an intricate process that increases susceptibility to sarcopenia and cardiovascular diseases. The accumulation of mitochondrial DNA (mtDNA) mutations is believed to contribute to mitochondrial dysfunction, potentially shortening lifespan. The mtDNA mutator mouse, a mouse model with a proofreading-deficient mtDNA polymerase γ, was shown to develop a premature aging phenotype, including sarcopenia,...
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