Article
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice.
Nature genetics - 1 Apr 2008
Vermulst Marc, Wanagat Jonathan, Kujoth Gregory C, Bielas Jason H, Rabinovitch Peter S, Prolla Tomas A, Loeb Lawrence A
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations are thought to have a causal role in many age-related pathologies. Here we identify mtDNA deletions as a driving force behind the premature aging phenotype of mitochondrial mutator mice, and provide evidence for a homology-directed DNA repair mechanism in mitochondria that is directly linked to the formation of mtDNA deletions. In addition, our results demonstrate that the rate...
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