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Article

Human stem cell aging: do mitochondrial DNA mutations have a causal role?

Aging cell - 1 Apr 2014

Baines Holly L, Turnbull Douglass M, Greaves Laura C

Abstract excerpt

A decline in the replicative and regenerative capacity of adult stem cell populations is a major contributor to the aging process. Mitochondrial DNA (mtDNA) mutations clonally expand with age in human stem cell compartments including the colon, small intestine, and stomach, and result in respiratory chain deficiency. Studies in a mouse model with high levels of mtDNA mutations due to a defect in the proofreading...

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Identifiers

PMID: 24382254
DOI: 10.1111/acel.12199
PMCID: PMC4331785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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