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Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice

6 Sept 2019

Abstract excerpt

The accumulation of mitochondrial DNA (mtDNA) mutations is a suspected driver of aging and age-related diseases, but forestalling these changes has been a major challenge. One of the best-studied models is the prematurely aging mtDNA mutator mouse, which carries a homozygous knock-in of a proofreading deficient version of the catalytic subunit of mtDNA polymerase-γ (PolgA). We investigated how voluntary exercise...

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PMID: 31489782
DOI: 10.1111/acel.13029

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