Article
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.
Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2005
Trifunovic Aleksandra, Hansson Anna, Wredenberg Anna, Rovio Anja T, Dufour Eric, Khvorostov Ivan, Spelbrink Johannes N, Wibom Rolf, Jacobs Howard T, Larsson Nils-Göran
Abstract excerpt
The mitochondrial theory of aging proposes that reactive oxygen species (ROS) generated inside the cell will lead, with time, to increasing amounts of oxidative damage to various cell components. The main site for ROS production is the respiratory chain inside the mitochondria and accumulation of mtDNA mutations, and impaired respiratory chain function have been associated with degenerative diseases and aging....
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