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Article

Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development.

PloS one - 1 Jan 2013

Mito Takayuki, Kikkawa Yoshiaki, Shimizu Akinori, Hashizume Osamu, Katada Shun, Imanishi Hirotake, Ota Azusa, Kato Yukina, Nakada Kazuto, Hayashi Jun-Ichi

Abstract excerpt

Mitochondrial DNA (mtDNA) mutator mice are proposed to express premature aging phenotypes including kyphosis and hair loss (alopecia) due to their carrying a nuclear-encoded mtDNA polymerase with a defective proofreading function, which causes accelerated accumulation of random mutations in mtDNA, resulting in expression of respiration defects. On the contrary, transmitochondrial mito-miceΔ carrying mtDNA with a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23418460
DOI: 10.1371/journal.pone.0055789
PMCID: PMC3572082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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