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Article

Mouse models of mitochondrial DNA defects and their relevance for human disease.

EMBO reports - 1 Feb 2009

Tyynismaa Henna, Suomalainen Anu

Abstract excerpt

Qualitative and quantitative changes in mitochondrial DNA (mtDNA) have been shown to be common causes of inherited neurodegenerative and muscular diseases, and have also been implicated in ageing. These diseases can be caused by primary mtDNA mutations, or by defects in nuclear-encoded mtDNA maintenance proteins that cause secondary mtDNA mutagenesis or instability. Furthermore, it has been proposed that mtDNA...

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Identifiers

PMID: 19148224
DOI: 10.1038/embor.2008.242
PMCID: PMC2637315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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