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Article

Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice.

PloS one - 1 Jan 2017

Someya Shinichi, Kujoth Gregory C, Kim Mi-Jung, Hacker Timothy A, Vermulst Marc, Weindruch Richard, Prolla Tomas A

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations are thought to have a causative role in age-related pathologies. We have shown previously that mitochondrial mutator mice (PolgD257A/D257A), harboring a proofreading-deficient version of the mtDNA polymerase gamma (POLG), accumulate mtDNA mutations in multiple tissues and display several features of accelerated aging. Calorie restriction (CR) is known to delay the onset of...

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Identifiers

PMID: 28158260
DOI: 10.1371/journal.pone.0171159
PMCID: PMC5291490

Genes

POLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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