Article
Mitochondrial DNA mutations in aging.
Progress in molecular biology and translational science - 1 Jan 2014
Khrapko Konstantin, Turnbull Doug
Abstract excerpt
The relationship of mitochondrial DNA mutations to aging is still debated. Most mtDNA mutations are recessive: there are multiple copies per cell and mutation needs to clonally expand to cause respiratory deficiency. Overall mtDNA mutant loads are low, so effects of mutations are limited to critical areas where mutations locally reach high fractions. This includes respiratory chain deficient zones in muscle...
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