Article
Premature ageing in mice expressing defective mitochondrial DNA polymerase.
Nature - 27 May 2004
Trifunovic Aleksandra, Wredenberg Anna, Falkenberg Maria, Spelbrink Johannes N, Rovio Anja T, Bruder Carl E, Bohlooly-Y Mohammad, Gidlöf Sebastian, Oldfors Anders, Wibom Rolf, Törnell Jan, Jacobs Howard T, Larsson Nils-Göran
Abstract excerpt
Point mutations and deletions of mitochondrial DNA (mtDNA) accumulate in a variety of tissues during ageing in humans, monkeys and rodents. These mutations are unevenly distributed and can accumulate clonally in certain cells, causing a mosaic pattern of respiratory chain deficiency in tissues such as heart, skeletal muscle and brain. In terms of the ageing process, their possible causative effects have been...
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