Article

Diminished sex hormone levels influence the risk of skewed X chromosome inactivation

2026-04-22

Abstract excerpt

<h4>Background</h4> X chromosome inactivation (XCI) is the mechanism which randomly silences one X chromosome to equalise gene expression between 46, XX females and 46, XY males. Though XCI is expected to result in a random pattern of mosaicism across tissues, some females display a significantly unbalanced ratio in immune cells, termed XCI-skew, in which ≥75% of cells have the same X inactivated. XCI-skew is ass...

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Literature Corpus work: 7cd2341e-23e6-5887-b8c4-543c8639ca68
DOI: 10.64898/2026.04.20.26351303

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