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Article

X-chromosome inactivation and its implications for human disease

2017-03-07

Abstract excerpt

<h4>ABSTRACT</h4> In humans and other mammals, female cells carry two X-chromosomes, whereas male cells carry a single X and Y-chromosome. To achieve an equal expression level of X-linked genes in both sexes, a dosage compensation mechanism evolved, which results in transcriptional silencing of one X-chromosome in females. X chromosome inactivation (XCI) is random with respect to the parental origin of the X, occ...

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Literature Corpus work
c3d95280-32f6-5538-b58b-04e348fca03e
DOI
10.1101/076950
Open publication

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