Defective X Chromosome Inactivation and Cancer Risk in Women

Abstract excerpt

<title>Abstract</title> <p>X-chromosome inactivation (XCI) is a fundamental mechanism in placental mammals that compensates for gene dosage differences between sexes. Using methylation levels of genes under XCI, we establish defective levels of XCI as a new source of interindividual variation among cancer types in females, characterized by strong <italic>XIST</italic>downregulation and upregulation and enrichment...

Topics

Open a Topic to create a Post that cites this publication.

• Chromosomes, Human, X
• Genes, X-Linked
• Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
• Genome, Human
• Organ Specificity
• Sequence Analysis, RNA
• Transcriptome
• X Chromosome Inactivation

Identifiers and source

Literature Corpus work

ce444532-acc1-5be1-a936-cf814a375e63

DOI

10.21203/rs.3.rs-4412470/v1