Article

Age acquired skewed X Chromosome Inactivation is associated with adverse health outcomes in humans

2022-04-05

Abstract excerpt

<h4>Background</h4> Ageing is a heterogenous process characterised by cellular and molecular hallmarks, including changes to haematopoietic stem cells, and is a primary risk factor for chronic diseases. X chromosome inactivation (XCI) randomly transcriptionally silences either the maternal or paternal X in each cell of XX,46 females to balance the gene expression with XY,46 males. Age acquired XCI-skew describes...

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Literature Corpus work: 08449f58-65b3-592c-966f-db31750f3118
DOI: 10.1101/2022.04.04.22272893

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