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Article

X-chromosome inactivation patterns depend on age and tissue but not conception method in humans

25 Jan 2023

Abstract excerpt

Female somatic X-chromosome inactivation (XCI) balances the X-linked transcriptional dosages between the sexes, randomly silencing the maternal or paternal X chromosome in each cell of 46,XX females. Skewed XCI toward one parental X has been observed in association with ageing and in some female carriers of X-linked diseases. To address the problem of non-random XCI, we quantified the XCI skew in different...

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PMID: 36695960
DOI: 10.1007/s10577-023-09717-9

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