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Defective X-chromosome inactivation and cancer risk in women

22 Feb 2025

Abstract excerpt

X-chromosome inactivation (XCI) is a fundamental mechanism in placental mammals that compensates for gene dosage differences between sexes. Using methylation levels of genes under XCI, we establish defective levels of XCI as a new source of interindividual variation among cancer types in females, characterized by a significant and consistent lowering of XIST expression and enrichment of differentially expressed...

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PMID: 39987288
DOI: 10.1038/s42003-025-07691-y

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