Promoter strength and position govern promoter competition via transcript-dependent insulation

Abstract excerpt

<h4>ABSTRACT</h4> Long-range competition between promoters within a shared regulatory landscape has been implicated in development and disease, but the determinants of promoter competition remain unclear. Here, we introduce diverse promoters into defined genomic sites within the Sox2 locus and measure how these insertions attenuate endogenous Sox2 expression. We find that the level of reduction in endogenous S...

Topics

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• Amino Acid Sequence
• Binding, Competitive
• Dimerization
• DNA
• Octamer Transcription Factor-3
• Protein Binding
• Protein Interaction Domains and Motifs
• Sequence Alignment

Identifiers and source

Literature Corpus work

7b2570d0-269e-5ee5-aaf3-2590c7bf3319

DOI

10.1101/2025.05.06.652547