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Article

Paradoxical gene regulation explained by competition for genomic sites

2025-11-27

Abstract excerpt

Understanding how opposing regulatory factors shape gene expression is essential for understanding complex biological systems. A motivating observation, drawn from cancer epigenetics, is that removing an activating factor can sometimes lead to higher, not lower, expression of a gene that is also subject to a repressing factor. Prior theoretical work explained this counterintuitive behavior by competition of repres...

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Literature Corpus work
75aefd42-243e-5771-85b4-284c5073668b
DOI
10.1101/2025.11.27.691022
Open publication

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Paradoxical gene regulation explained by competition for genomic sitesDOI 10.1101/2025.11.27.691022
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