Article

Synthetic genomic dissection of enhancer context sensitivity and synergy

2025-08-15

Abstract excerpt

<h4>ABSTRACT</h4> Noncoding disease and trait-associated genetic variation is frequently interpreted in the context of genomic regulatory elements such as DNase I hypersensitive sites (DHSs). But while most DHSs lie within a few kilobases of another DHS, regulatory elements are typically analyzed individually without accounting for their neighbors. We characterize multiple heterotypic DHS combinations from differ...

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Literature Corpus work: 6040bac2-dc45-5fd7-921a-58353c31ecd0
DOI: 10.1101/2025.08.13.669251

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