Article

Compatibility logic of human enhancer and promoter sequences

2021-10-24

Abstract excerpt

Gene regulation in the human genome is controlled by distal enhancers that activate specific nearby promoters. One model for the specificity of enhancer-promoter regulation is that different promoters might have sequence-encoded preferences for distinct classes of enhancers, for example mediated by interacting sets of transcription factors or cofactors. This “biochemical compatibility” model has been supported by...

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Literature Corpus work: 34a2c729-1ee5-5efe-94c8-826da510a128
DOI: 10.1101/2021.10.23.462170

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