Article

Resolution of a human super-enhancer by targeted genome randomisation

2025-01-14

Abstract excerpt

Human gene expression is controlled from distance via enhancers, which can form longer ‘super-enhancer’-regions of intense regulatory activity. Whether super-enhancers constitute a separate regulatory paradigm remains unclear, largely due to the difficulty of dissecting the contributions and interactions of individual elements within their natural chromosomal context. To address this challenge, we developed enhanc...

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Literature Corpus work: 08c7521f-32a8-5a74-a42b-4cb6429c84b4
DOI: 10.1101/2025.01.14.632548

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