Article

A flexible repertoire of transcription factor binding sites and diversity threshold determines enhancer activity in embryonic stem cells

2020-04-18

Abstract excerpt

<h4>ABSTRACT</h4> Transcriptional enhancers are critical for development, phenotype evolution and often mutated in disease contexts; however, even in well-studied cell types, the sequence code conferring enhancer activity remains unknown. We found genomic regions with conserved binding of multiple transcription factors in mouse and human embryonic stem cells (ESCs) contain on average 12.6 conserved transcription...

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Identifiers and source

Literature Corpus work: 0831ae14-38a6-51da-965f-8a4226d3b203
DOI: 10.1101/2020.04.17.046664

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