Article

Super-promoters: Cooperativity between juxtaposed promoters

2023-05-25

Abstract excerpt

<title>Abstract</title> <p>The coordination of transcription through enhancers and promoters is a fundamental process that has a central role in development and disease <sup>1–3</sup>. Convergent transcription, i.e., the collision of sense and antisense transcription, is ubiquitous in mammalian genomes <sup>4–8</sup> and believed to diminish RNA expression <sup>9,10</sup>. Recently, antisense transcription downst...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 324d36c0-3b83-5134-b2a3-2fbe0e02a6b3
DOI: 10.21203/rs.3.rs-2803901/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Super-promoters: Cooperativity between juxtaposed promotersDOI 10.21203/rs.3.rs-2803901/v1Read

Compatibility logic of human enhancer and promoter sequencesSemantic proximity Read

Dynamics and Topology of Human Transcribed <i>Cis</i> -regulatory ElementsSemantic proximity Read

Super-enhancers in the control of cell identity and disease.Semantic proximity Read

Widespread enhancer co-activity identified by multimodal single cell analysisSemantic proximity Read

What are super-enhancers?Semantic proximity Read

Shared regulation and functional relevance of local gene co-expression revealed by single cell analysisSemantic proximity Read

Mammalian enhancers and GWASs act proximally and seldom skip active genesSemantic proximity Read

Promoter strength and position govern promoter competition via transcript-dependent insulationSemantic proximity Read

A new class of constitutively active super-enhancers is associated with fast recovery of 3D chromatin loopsSemantic proximity Read

Global identification of mammalian host and nested gene pairs reveal tissue-specific transcriptional interplaySemantic proximity Read

Summarizing internal dynamics boosts differential analysis and functional interpretation of super enhancersSemantic proximity Read

Transcription factor expression is the main determinant of variability in gene co-activitySemantic proximity Read