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Article

A Novel Chromatin-Opening Element for Stable Long-term Transgene Expression

2019-05-03

Abstract excerpt

<h4>ABSTRACT</h4> Long-term stable expression of transgenes in mammalian cells is a challenge in gene therapy, recombinant protein production, and mammalian synthetic biology due to epigenetic silencing and position effect variegation. While multiple classes of regulatory elements have been discovered and proposed to help stabilize expression, the most efficacious has been the Ubiquitous Chromatin Opening Element...

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Literature Corpus work
fdf36ddd-3e2f-5dd1-a4c3-8486098c74d6
DOI
10.1101/626713
Open publication

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A Novel Chromatin-Opening Element for Stable Long-term Transgene ExpressionDOI 10.1101/626713
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