Article

NSUN2 drives intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signalling

2025-04-17

Abstract excerpt

Colorectal cancer is initiated by loss of the APC gene, which drives expansion of LGR5+ intestinal stem cell (ISC) populations. Whilst LGR5+ ISC expansion is a critical step for tumour initiation and progression, its regulation is poorly understood. Emerging evidence suggests post-transcriptional RNA modifications play a key role in cancer biology, but their role in CRC initiation has not been explored. Here, we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7adbea3c-d899-5678-b79d-84ced04a9285
DOI: 10.1101/2025.04.11.648351

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NSUN2 drives intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signallingDOI 10.1101/2025.04.11.648351Read

NSUN5 promotes tumorigenic phenotypes through the WNT signaling pathway and immunosuppression of CD8+ T cells in gastric cancer.Semantic proximity Read

The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to DifferentiateSemantic proximity Read

An integrative multi-omics framework identifies epigenetic dysregulation of <i>HAND2</i> as a potential primary driver of impaired enteric neural crest cell differentiation in Hirschsprung DiseaseSemantic proximity Read

Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferationSemantic proximity Read

Dynamic intestinal stem cell plasticity and lineage remodeling by a nutritional environment relevant to human risk for tumorigenesisSemantic proximity Read

NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.Semantic proximity Read

Clinical Implications of APC Mutation Driven Dysregulation of Intestinal Regulators of Proliferation and Differentiation: A Systematic Review Identifying Factors Governing Onset of Colorectal CarcinomaSemantic proximity Read

Genome-wide analysis of DNA methylation in Hirschsprung enteric precursor cells: unraveling the epigenetic landscape of enteric nervous system development.Semantic proximity Read

G9a controls pluripotent-like identity and tumor-initiating function in human colorectal cancerSemantic proximity Read

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.Semantic proximity Read

Inhibition of histone methyltransferase EZH2 for immune interception of colorectal cancer in Lynch syndromeSemantic proximity Read

PKN2 regulates cell-junctions to limit colitisSemantic proximity Read