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Article

The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate

1 Dec 2011

Abstract excerpt

Homeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin. In the epidermis, this methyltransferase is found in a defined sub-population of hair...

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PMID: 22144916
DOI: 10.1371/journal.pgen.1002403

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