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An integrative multi-omics framework identifies epigenetic dysregulation of <i>HAND2</i> as a potential primary driver of impaired enteric neural crest cell differentiation in Hirschsprung Disease

2026-06-12

Abstract excerpt

Hirschsprung disease (HSCR) is a congenital neurodevelopmental disorder characterized by segmental aganglionosis due to impaired developmental processes of enteric neural crest cells (NCCs). Despite being the leading genetic cause of functional intestinal obstruction in early childhood, HSCR represents a paradigmatic challenge in precision medicine: its multifactorial etiology, complex gene-environment interaction...

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Literature Corpus work
a50ab8c7-cdcd-5d41-a8d6-725b1a334ee3
DOI
10.64898/2026.06.11.26354426
Open publication

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An integrative multi-omics framework identifies epigenetic dysregulation of <i>HAND2</i> as a potential primary driver of impaired enteric neural crest cell differentiation in Hirschsprung DiseaseDOI 10.64898/2026.06.11.26354426
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