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Article

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer.

Cell - 2 Jul 2015

Man Si Ming, Zhu Qifan, Zhu Liqin, Liu Zhiping, Karki Rajendra, Malik Ankit, Sharma Deepika, Li Liyuan, Malireddi R K Subbarao, Gurung Prajwal, Neale Geoffrey, Olsen Scott R, Carter Robert A, McGoldrick Daniel J, Wu Gang, Finkelstein David, Vogel Peter, Gilbertson Richard J, Kanneganti Thirumala-Devi

Abstract excerpt

Colorectal cancer is a leading cause of cancer-related deaths. Mutations in the innate immune sensor AIM2 are frequently identified in patients with colorectal cancer, but how AIM2 modulates colonic tumorigenesis is unknown. Here, we found that Aim2-deficient mice were hypersusceptible to colonic tumor development. Production of inflammasome-associated cytokines and other inflammatory mediators was largely intact...

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Source

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Identifiers

PMID: 26095253
DOI: 10.1016/j.cell.2015.06.001
PMCID: PMC4491002

Genes

AIM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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