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Article

G9a controls pluripotent-like identity and tumor-initiating function in human colorectal cancer

15 Dec 2020

Abstract excerpt

Colorectal tumors are hierarchically organized and governed by populations of self-renewing cancer stem cells, representing one of the deadliest types of cancers worldwide. Emergence of cancer stemness phenotype depends on epigenetic reprogramming, associated with profound transcriptional changes. As described for pluripotent reprogramming, epigenetic modifiers play a key role in cancer stem cells by establishing...

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PMID: 33323965
DOI: 10.1038/s41388-020-01591-7

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