Article

Clinical Implications of APC Mutation Driven Dysregulation of Intestinal Regulators of Proliferation and Differentiation: A Systematic Review Identifying Factors Governing Onset of Colorectal Carcinoma

2026-03-11

Abstract excerpt

<title>Abstract</title> <p> <bold>Objective:</bold> With a focus on clinical implications toward early detection, this study investigates how APC loss disrupts intestinal stem cell regulatory networks by simultaneously enhancing proliferation signaling programs and suppressing key differentiation enforcers, thereby driving colorectal carcinoma development. <bold>Background:</bold> Colorectal cancer commonly b...

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Literature Corpus work: 2528104a-ba50-5256-b9ee-0446019b90ad
DOI: 10.21203/rs.3.rs-9076136/v1

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Clinical Implications of APC Mutation Driven Dysregulation of Intestinal Regulators of Proliferation and Differentiation: A Systematic Review Identifying Factors Governing Onset of Colorectal CarcinomaDOI 10.21203/rs.3.rs-9076136/v1Read

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