NSUN5 promotes tumorigenic phenotypes through the WNT signaling pathway and immunosuppression of CD8+ T cells in gastric cancer.

doi:10.1016/j.cellsig.2024.111475

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Article

NSUN5 promotes tumorigenic phenotypes through the WNT signaling pathway and immunosuppression of CD8+ T cells in gastric cancer.

Cellular signalling - 1 Dec 2024

Liu Shuhao, Liu Yong, Zhou Yijun, Xia Gaoshui, Liu Haibo, Zeng Yu, Pei Zhihui, Cao Jing, Jing Guifang, Zou Hailin, Liao Chuanwen

Abstract excerpt

NSUN5, a key member of the M5C methylation family, plays a significant role in fundamental biological processes like cell proliferation and differentiation. However, its specific function and mechanisms in gastric cancer remain insufficiently understood. Initially, we examined NSUN5's differential expression in gastric cancer versus normal tissues, along with survival trends, associated signaling pathways, and...

Topics

Stomach Neoplasms
Humans
Wnt Signaling Pathway
CD8-Positive T-Lymphocytes
Cell Line, Tumor
Animals
Cell Proliferation
Mice
Carcinogenesis
Male
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cell Movement

Proto-Oncogene Mas

Gene Expression Regulation, Neoplastic

Phenotype

Mice, Nude

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 39428025
DOI: 10.1016/j.cellsig.2024.111475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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