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Article

Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation

12 Apr 2013

Abstract excerpt

OBJECTIVE: Colorectal cancer (CRC) is a major contributor to cancer mortality and morbidity. LIM kinase 2 (LIMK2) promotes tumour cell invasion and metastasis. The objectives of this study were to determine how LIMK2 expression is associated with CRC progression and patient outcome, and to use genetically modified Drosophila and mice to determine how LIMK2 deletion affects gastrointestinal stem cell regulation...

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Identifiers

PMID: 23585469
DOI: 10.1136/gutjnl-2012-303883

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