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Article

Genome-wide analysis of DNA methylation in Hirschsprung enteric precursor cells: unraveling the epigenetic landscape of enteric nervous system development.

Clinical epigenetics - 9 Mar 2021

Villalba-Benito Leticia, López-López Daniel, Torroglosa Ana, Casimiro-Soriguer Carlos S, Luzón-Toro Berta, Fernández Raquel María, Moya-Jiménez María José, Antiñolo Guillermo, Dopazo Joaquín, Borrego Salud

Abstract excerpt

BACKGROUND: Hirschsprung disease (HSCR, OMIM 142623) is a rare congenital disorder that results from a failure to fully colonize the gut by enteric precursor cells (EPCs) derived from the neural crest. Such incomplete gut colonization is due to alterations in EPCs proliferation, survival, migration and/or differentiation during enteric nervous system (ENS) development. This complex process is regulated by a...

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Identifiers

PMID: 33750457
DOI: 10.1186/s13148-021-01040-6
PMCID: PMC7942176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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