Article

Dynamic intestinal stem cell plasticity and lineage remodeling by a nutritional environment relevant to human risk for tumorigenesis

2022-03-19

Abstract excerpt

NWD1, a purified rodent diet establishing mouse exposure to key nutrients recapitulating levels that increase risk for intestinal cancer, reproducibly causes sporadic intestinal and colonic tumors in the mouse, reflecting human etiology, incidence, frequency and lag with developmental age. Complex NWD1 reprogramming of stem cells and lineages was deconvolved by bulk and scRNAseq, scATACseq, functional genomics an...

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Literature Corpus work: feb56f34-c569-56cb-bd69-88b5cb94b323
DOI: 10.1101/2022.03.17.484800

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