Article

PKN2 regulates cell-junctions to limit colitis

2025-12-17

Abstract excerpt

Intestinal barrier failure is a defining feature of inflammatory bowel disease and a key driver of inflammation-associated colorectal cancer. However, the epithelial mechanisms that preserve barrier stability during inflammatory stress remain incompletely defined. Here, we identify the Rho-regulated kinase PKN2 as a non-redundant safeguard of tight junction integrity and a candidate tumour suppressor in colitis-as...

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Literature Corpus work: bab98ffb-a6e0-51be-be18-1b8077ab93c7
DOI: 10.64898/2025.12.15.694339

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