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Inhibition of histone methyltransferase EZH2 for immune interception of colorectal cancer in Lynch syndrome

13 Feb 2025

Abstract excerpt

Colorectal precancers in Lynch syndrome (LS) exhibit a distinct immune profile, presenting unique opportunities for developing immune-interception strategies to prevent carcinogenesis. Epigenetic modulation by EZH2 of immune-related genes is implicated in the carcinogenesis of different cancer types, including colorectal cancer. This study utilizes a mouse model of LS and ex vivo colonic organoids to assess the...

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PMID: 39946195
DOI: 10.1172/jci.insight.177545

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