Article

Promoter proximal pausing limits Yki-induced tumorous growth in <i>Drosophila</i>

2019-10-21

Abstract excerpt

Promoter proximal pausing (PPP) of RNA Polymerase II has emerged as a crucial rate-limiting-step in the regulation of gene expression. Regulation of PPP is brought about by complexes 7SK snRNP, P-TEFb (Cdk9/cycT) and the Negative Elongation Factor (NELF) which are highly conserved from Drosophila to humans. Here we show that RNAi-mediated depletion of bin3 or Hexim of the 7SK snRNP complex or depletion of indiv...

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Literature Corpus work: 7ab58849-ddb0-51ed-bc76-8055fed1ec26
DOI: 10.1101/813022

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