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Article

Tissue specific function of the <i>Drosophila</i> 7SK snRNP in controlling motoneuron synaptic growth

2025-05-01

Abstract excerpt

The 7SK snRNP is a ribonucleoprotein complex comprising the non-coding RNA 7SK and the associated proteins MePCE, LARP7, and HEXIM. It regulates transcription in higher eukaryotes by sequestering the positive transcription elongation factor (P-TEFb), preventing premature entry of RNA Polymerase II in elongation. Loss of LARP7 in humans causes the Alazami syndrome, marked by restricted growth, impaired movement, an...

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Literature Corpus work
406b8161-67a4-5940-8904-2c2dc464d896
DOI
10.1101/2025.04.29.651232
Open publication

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Tissue specific function of the <i>Drosophila</i> 7SK snRNP in controlling motoneuron synaptic growthDOI 10.1101/2025.04.29.651232
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