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Article

A switch in transcription and cell fate governs the onset of an epigenetically-deregulated tumor in Drosophila.

eLife - 21 Mar 2018

Torres Joana, Monti Remo, Moore Ariane L, Seimiya Makiko, Jiang Yanrui, Beerenwinkel Niko, Beisel Christian, Beira Jorge V, Paro Renato

Abstract excerpt

Tumor initiation is often linked to a loss of cellular identity. Transcriptional programs determining cellular identity are preserved by epigenetically-acting chromatin factors. Although such regulators are among the most frequently mutated genes in cancer, it is not well understood how an abnormal epigenetic condition contributes to tumor onset. In this work, we investigated the gene signature of tumors caused...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29560857
DOI: 10.7554/eLife.32697
PMCID: PMC5862528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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