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Catalytic activity of the Bin3/MEPCE methyltransferase domain is dispensable for 7SK snRNP function in <i>Drosophila melanogaster</i>

2023-06-05

Abstract excerpt

<h4>ABSTRACT</h4> Methylphosphate Capping Enzyme (MEPCE) monomethylates the gamma phosphate at the 5’ end of the 7SK noncoding RNA, a modification thought to protect 7SK from degradation. 7SK serves as a scaffold for assembly of a snRNP complex that inhibits transcription by sequestering the positive elongation factor P-TEFb. While much is known about the biochemical activity of MEPCE in vitro , little is known...

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Literature Corpus work
0c983436-a293-5323-b71d-0d14c164e8a8
DOI
10.1101/2023.06.01.543302
Open publication

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