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Tau-induced increase in promoter-proximal RNA polymerase II pausing is linked to suppressed expression of long neuronal genes in a <i>Drosophila</i> tauopathy model

2026-03-30

Abstract excerpt

Tauopathies, including Alzheimer’s disease, are age-related neurodegenerative disorders characterized by abnormal phosphorylation and buildup of microtubule-associated protein tau. Gene expression dysregulation is a key molecular feature of tauopathies, but how aging and disease interact to disrupt crucial transcriptional regulators and pathways remains largely unknown. Here, we examined how pathological tau affec...

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Literature Corpus work
c17c3ddd-97da-5a01-8254-65ab3c658817
DOI
10.64898/2026.03.28.709859
Open publication

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Tau-induced increase in promoter-proximal RNA polymerase II pausing is linked to suppressed expression of long neuronal genes in a <i>Drosophila</i> tauopathy modelDOI 10.64898/2026.03.28.709859
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