Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size

1 Dec 2017

Abstract excerpt

The Hippo/Yki and RB/E2F pathways both regulate tissue growth by affecting cell proliferation and survival, but interactions between these parallel control systems are poorly defined. In this study, we demonstrate that interaction between Drosophila E2F1 and Sd disrupts Yki/Sd complex formation and thereby suppresses Yki target gene expression. RBF modifies these effects by reducing E2F1/Sd interaction. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Hippo pathway signaling and YAP/TAZ
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29207260
DOI: 10.1016/j.devcel.2017.10.033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ SizePMID 29207260Read ↗

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control.Semantic proximity Read ↗

The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression.Semantic proximity Read ↗

The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.Semantic proximity Read ↗

Elucidation of a universal size-control mechanism in Drosophila and mammals.Semantic proximity Read ↗

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.Semantic proximity Read ↗

The Hippo signalling pathway coordinates organ growth and limits developmental variability by controlling dilp8 expression.Semantic proximity Read ↗

The Drosophila RASSF homolog antagonizes the hippo pathway.Semantic proximity Read ↗

A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie.Semantic proximity Read ↗

The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6.Semantic proximity Read ↗

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.Semantic proximity Read ↗

Control of mitochondrial dynamics by dPGC1 limits Yorkie-induced oncogenic growth in <i>Drosophila</i>Semantic proximity Read ↗

Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.