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Article

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development.

Proceedings of the National Academy of Sciences of the United States of America - 12 May 2009

Barboric Matjaz, Lenasi Tina, Chen Hui, Johansen Eric B, Guo Su, Peterlin B Matija

Abstract excerpt

Eukaryotic gene expression is commonly controlled at the level of RNA polymerase II (RNAPII) pausing subsequent to transcription initiation. Transcription elongation is stimulated by the positive transcription elongation factor b (P-TEFb) kinase, which is suppressed within the 7SK small nuclear ribonucleoprotein (7SK snRNP). However, the biogenesis and functional significance of 7SK snRNP remain poorly...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19416841
DOI: 10.1073/pnas.0903188106
PMCID: PMC2683122

Genes

LARP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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