Article

Activity-assembled nBAF complex mediates rapid immediate early gene transcription by regulating RNA Polymerase II productive elongation

2023-12-30

Abstract excerpt

<h4>Summary</h4> Signal-dependent RNA Polymerase II (Pol2) productive elongation is an integral component of gene transcription, including those of immediate early genes (IEGs) induced by neuronal activity. However, it remains unclear how productively elongating Pol2 overcome nucleosomal barriers. Using RNAi, three degraders, and several small molecule inhibitors, we show that the mammalian SWI/SNF complex of neu...

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Literature Corpus work: 3ba265f9-fc5e-5bc3-9409-28ea5293759f
DOI: 10.1101/2023.12.30.573688

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